Waching daily Aug 1 2018

hello guys it's Wesley McKinley coming at you again today with a video number

seven I'm quite I'm very excited about everything I love doing this I love

sharing the music with you and I'm hoping that you are watching

of my videos and you're taking my advice and checking out these bands because

it's some pretty awesome stuff today I'm gonna change it up a little bit I've

been doing reviews of music but today I want to sort of just share a little

story with you I don't wanna I don't want to make it seem like you know this

is something you should go out and do it was just something I did I'm not very

you know I look back on this kind of sneaky and underhanded and everything is

sort of funny and I would like to share that with you today

okay now this this is it's kind of funny stories back when beckon I think it was

1999 or maybe 2000 I'm not sure but I was

going to school in Austin Texas I was taking classes at ACC you know the thing

that most people do is they try to get their basics out of the way out of

junior college because I feel like me and you don't have the money you can

have them that'll help you out a little bit so but anyway I was I was going to

school and I was working full-time at Barton Creek Resort in Austin and I I

had a friend at work that just came up to me one day

hey hey I know you like music do you want to come with me and check out ac/dc

in the San Antonio and of course I was like yeah man that sounds awesome let's

let's go you know so we went about all this stuff

and we got tickets I think it was like it was like 50 or 60 bucks a ticket and

we're stoked it was very exciting and we're we were heading down

there we were jamming out the whole way you know pumping the ac/dc

it was a good time and we get there and we're the Alamodome and we go inside

and we find the place where our seats are and we're all stoked you know

excited going to our seats and then we find our seats

and we're up against the back wall of the Alamo dome you know you have to

strain your eyes to see the stage at all and I was like how we gonna rock out all

the way back here and so I started thinking I I told my friend I'll

be back in a little bit and I started thinking about you know how I could get

closer to the stage and you know I was being sneaky and doing all this

stuff well I started walking around and everything and I actually walked down to

the floor and I see the entrance to the floor you know where you could they're

standing room on the floor now I'm gonna get in there you know I'm

gonna see the show and I feel bad about this but I went back there and I sort of

started watching that lady that was taking the tickets and I waited for her

and she was very nice which is another reason I felt bad but

she was she was very nice she was talking to people and everything so I

was like oh you know this is my opportunity so I knew that I couldn't

just sneak in because she was the main person in front but then she gave

the nod to people behind saying that's okay let him go to a seat or whatever

and or to there standing area but I saw her start talking to this group of people so

I I sort of just snuck around back of her and then I started walking out and

you know I I actually I stopped and talked to her and I was like hey you

know I I'm looking for the restroom I need to go to the restroom before the

show starts and everything I don't want to leave in the middle of the

show and so yeah you know the bathrooms over this way and everything and I was

you're so nice thank you so much but what I was doing is I was getting

her to remember my face and remember that I was yeah I wanted to give her the

impression that I was already down there and I was just coming out and she was

helping me and stuff so she she told me where the restroom was

I was like I talked to her for a minute so she would definitely remember me and

then I I went to the restroom and I I went in there and I'm washing my hands

and I came back out and you know I just started walking to the

entrance to the floor well you know as I got closer I was like a thank you you

know it was so nice of you and everything yeah sure

she's like go on in and so I mean I didn't do that I didn't you know give

dumbstruck in front of her anything but I was you

know inside I was like oh my gosh it worked good work

so I start walking in she just gives a nod to the person behind her he's

okay he he was down there before and so I got to go into the I was standing on

the floor and this is pretty amazing I was I ended up like you know pretty

close to the beginning out I think it was like 17 the row or something 17 back

I was pretty close I actually Angus Young when he was doing

his guitar thing he came out cross on top of the audience and had this whole

stage set up in the middle of the floor I ended up right by that it was

kind of cool I felt really bad for my friend because he had to watch the show

from the the wall and I I felt really bad about that but you know I was so

happy that you know I got to go up there it was kind of awesome I didn't

think twice about it so I just want to share that story with

you because I started thinking about it earlier today and I started chuckling

you know that and I just wanted to share that experience with you and please

don't think that I'm a shady person that it's not something that I do on the

regular basis and hey I do feel bad about it so just keep that in mind you know I

don't recommend people sneak into this stuff but you know I paid 60

bucks I'm gonna see a good show haha but anyway yeah that's my story so I hope it

was it was fun for you it was definitely fun for me and it caused me to laugh a

little bit I hope it you know brought a little laughter into your life but yet I have

also included in the description of this video below I have put a link to a

YouTube video it's the greatest hits of ac/dc

so I want you to enjoy and have great time

well it is the end of the video and I have a couple of things to ask you I

would love it if you would you know give me the thumbs up

are you know if you thought my actions were sneaky and underhanded and

everything you can give me the thumbs down but I would also like you to

subscribe to the channel I'm gonna be posting more things like this in the

future more reviews of albums anything to sort of open up your life and make it

a little bit better make it a little bit more enjoyable so and then also the most

important thing you could do for me is leave a comment below this video I would

you know you could tell me what you thought telling me you know anything

what you want me to talk about in the future if you have any suggestions of

your own on albums that I should listen to maybe I should I haven't heard feel

free I would love love to hear from you so until next time my friend have a

great day

For more infomation >> Video # 7 - Highway to rock n roll - Duration: 11:32.

-------------------------------------------

Overseas Investment Amendment Bill - Committee Stage - Video 8 - Duration: 5:23.

For more infomation >> Overseas Investment Amendment Bill - Committee Stage - Video 8 - Duration: 5:23.

-------------------------------------------

Overseas Investment Amendment Bill - Committee Stage - Video 4 - Duration: 10:18.

For more infomation >> Overseas Investment Amendment Bill - Committee Stage - Video 4 - Duration: 10:18.

-------------------------------------------

Overseas Investment Amendment Bill - Committee Stage - Video 12 - Duration: 5:09.

For more infomation >> Overseas Investment Amendment Bill - Committee Stage - Video 12 - Duration: 5:09.

-------------------------------------------

Overseas Investment Amendment Bill - Committee Stage - Video 10 - Duration: 3:56.

For more infomation >> Overseas Investment Amendment Bill - Committee Stage - Video 10 - Duration: 3:56.

-------------------------------------------

WP testing video with captions uploaded on 1 Aug 2018 - Duration: 3:30.

In this lecture, I want to talk about the type of stimuli that we would use

to record the evoke potentials that we are looking at.

From the cochlear microphonic through to the summating potential,

dendritic potential and the compound action potential.

Here's the hair cell transfer curve for the outer hair cell.

It is symmetric, it has an operating point of 50%,

which means that the displacement of the hair cell, hair bundles

will create an alternating current which you can see here.

The cochlear microphonic waveform is an alternating current waveform.

You want a single polarity stimulus

because if you have an alternating polarity stimulus

and you average it over time, of course you can average it out to 0.

Your single polarity stimulus should be of low frequency

to avoid contaminating the response with inner hair cell activity.

The inner hair cells are velocity, not displacement-coupled.

So, the lower the frequency of the tone that is presented,

the less likely the inner hair cells will contribute.

The other thing to remember is that the round-window electrode sits

right near the base of the cochlea.

It's consistent with the high frequency region

of the cochlear, or of the hair cells.

The loudness of the sound must be high enough

to generate activity in these basal hair cells.

Not only do you need a low frequency single polarity stimulus,

you need it to be loud enough to generate basal hair cell activity.

Under pathological conditions, outer hair cells can do many things.

For example, the operating point might change due to

a static displacement on the basilar membrane.

Look at the first example, point A, which shows

a normal physiological cochlea.

We have the operating point at 50%.

You can see this lovely, symmetric cochlear microphonic

or current that occurs in the outer hair cells.

On the other hand, if we have a static displacement

of the basilar membrane down to what is called timpani,

this is something that we see with Ménière's Disease for example.

We have an endolymphatic hydrops of the scala media,

which pushes through pressure a displacement down

on the basilar membrane.

This causes a biais of the outer hair cells

since it's displacement-coupled.

In fact, what we see is an asymmetric current

that would saturate on one side before the other side.

You can see now how you might look at the cochlear microphonic

to differently diagnose what's happening with the outer hair cells.

On the other hand, if something were to occur,

that caused your basilar membrane to move up towards scala vestibuli.

No particular pathology would create this.

But just because we can't think of what it might be

doesn't mean it doesn't happen.

You get a saturation on the other side of the cochlear microphonic.

So, you can see how the cochlear microphonic

might enable us to see what

the operating point of the outer hair cells could be.

On the other hand, instead of a change in the operating point,

mechano-electrical transduction channels

might be closed off or inactivated due to things like

loud noise, ototoxic drugs,

or any type of blockage that can occur.

In this case, there would be a reduction in the maximum

of the saturation currents.

You'd still get a symmetric-looking cochlear microphonic

but the maximum amplitude of the cochlear microphonic would be reduced.

That is cochlear microphonic and how to use it with electrocochleography,

how we might differentially diagnose a problem there.

Let's look at the stimulus we need to measure the summating potential,

the compound action potential and the dendritic potential.

In this case, we want to get rid of the cochlear microphonic.

To do that, we need an alternating tone burst.

We also want to capture the activity from the inner hair cells

and from the neurons.

We need a high frequency, alternating tone burst that gives us

the best representation of the activity at the base of the cochlea,

which is where the round-window electrode is situated.

In this case, for humans,

the activity at the round window of the cochlea

is consistent with a characteristic frequency

of about 8 kHz.

We want to present a high frequency,

roughly 8 to 10 kHz tone burst that is alternating in nature.

In that way, when we average, we're averaging out not just the noise

but also a cochlear microphonic.

On the left-hand side, for the human, we can see the summating potential

and a compound action potential.

On the right hand side, it is very similar to what we see

in the animal model, in the guinea pig.

Here, we see the response that we will get with a single polarity

versus an alternating polarity click.

It is a click, it's not a long duration tone burst.

The cochlear microphonic's quality is not incredible

but you can still see it in the bottom trace.

If we look at the top trace, you can see a rarefaction stimulus

and a condensation stimulus that create the response.

Rarefaction plus condensation gets rid of the cochlear microphonic.

So we get rid of any alternating component.

We're left with the summating potential,

followed by the compound action potential.

On the other hand, if we subtract the rarefaction

and the condensation responses,

we find that the cochlear microphonic is maximised or amplified,

We also get a slight compound action potential

due to the difference in magnitude of the response

produced by the rarefaction versus condensation response.

Simply, from this diagram, it shows that if you add the two responses,

you null the cochlear microphonic.

If you substract the two responses you magnify it.

The next point is:

How do you measure the amplitude of the response you obtain?

Here is an example of a high frequency alternating tone burst

that's been used, in fact a click has been used,

with an 80dBnHL sound.

The response shows the summating potential

followed by the action potential.

There are two ways you can look at the magnitude of the response.

The first one is that you measure from baseline

what the magnitude of the summating potential is

and then, from the tip of the summating potential,

from the greatest point of the summating potential,

you can measure what the magnitude of the action potential is.

In this example, the summating potential

and the action potentials are in a negative direction.

But for a high-frequency tone burst, for reasons of polarity

and direction of currents, etc. the summating potential is often

a positive response compared to the action potential.

The left shows a summating potential followed by an action potential.

But on the right, both potentials are measured

in amplitude from the baseline.

Either could be correct but you need to clearly articulate

how you've measured each.

This final example shows the adaptation

that occurs when you are presenting click trains.

This example comes from a paper by ?? Santarelli,

which is talking about auditory neuropathy.

But this slide depicts what happens in control subjects,

in normal hearing, non-pathological subjects.

If you have a look at the click train that is presented – 11 clicks.

They present one, followed by a pause of about 15 ms

and then they present a series of 10 click trains.

You can see, if you look at part C that the summating potential

is not particularly affected by how rapid

the click stimuli are presented.

On the other hand, the compound action potential

is highly adapted by this rapid presentation of stimuli.

So when you are measuring the compound action potential,

bear in mind how much time you need to allow for recovery of the response

before you measure it again.

For more infomation >> WP testing video with captions uploaded on 1 Aug 2018 - Duration: 3:30.

-------------------------------------------

Remake Video Raditya Dika 4 JUTA SUBSCRIBERS! GIVEAWAY MOBIL! by TI ONE DAVIDTOA - Duration: 3:22.

Remake Video Raditya Dika 4 MILLION SUBSCRIBERS! GIVEAWAY CAR! by TI ONE DAVIDTOA

For more infomation >> Remake Video Raditya Dika 4 JUTA SUBSCRIBERS! GIVEAWAY MOBIL! by TI ONE DAVIDTOA - Duration: 3:22.

-------------------------------------------

Chocolate Dora Handbag Cake Design for Birthday Cake Tutorial Video - Duration: 11:11.

Dora Cake Design