Thứ Tư, 4 tháng 1, 2017

Waching daily Jan 4 2017

On the Sunday morning talk shows this past weekend, CNN commentator Van Jones made it

absolutely clear that the Democratic Party has to move beyond the days of Clinton, both

Hillary and Bill Clinton.

Specifically, Van Jones called out the fact that the Clinton Administration and Democratic

policies basically since the Clinton Administration had thrown black people under the bus with

their calls for prison reform, mass incarcerations, and they threw workers under the bus with

NAFTA and other disastrous trade deals, and the Democratic Party's overall embrace of

corporatism since the days of Bill Clinton.

Now, this analysis by Van Jones, not only is it 100% spot on, it's something that the

Democratic Party needs to hear.

It's something that Bernie Sanders hit on again and again during his campaign, and it's

something that a lot of Democrats refuse to acknowledge as reality.

There's too many progressive pundits out there right now saying that we still need to be

a little bit moderate.

We need to work with Republicans, not against them, and here's the kicker, a lot of them

out there are comparing the progressive wing of the Democratic Party to the Tea Party,

saying that they're just as dangerous to the Democratic Party.

Listen, the Democratic Party in the 20th Century became the party of working class America

by fighting against corporate interest and making sure that workers and average citizens

and the underclass were completely taken care of so that they didn't slip further into poverty

or fall into these horrible health crises.

That's what the Democratic Party built.

It began earnestly with FDR and continued on since then until the days of Bill Clinton.

That's when the party shifted a little bit more to the center.

It happened again with Barrack Obama even though he promised us hope and change.

He brought us nothing but liberal corporatism.

That's why the party is in the situation that it is today.

What massive gains has the Democratic Party had since the days of Bill Clinton?

Sure, we elected the first black president, and then what?

Then what happened to American workers, to America in general?

No huge progressive gains as a result of President Obama.

All of the gains that have been made over the last recent years were through voter powered

initiatives at the local and state level.

The Democratic Party needs to take a page out of these local playbooks because those

people actually understand that progressivism wins, progressivism is popular with both Democrats

and Republicans, and when you keep corporations, corporate influence out of it, you can achieve

great things.

That's what Van Jones was talking about, that's what Bernie Sanders has been talking about,

and that's what the entire Democratic Party needs to wake up and realize if they want

to remain relevant in today's political culture.

For more infomation >> Van Jones Says Clinton Days Are Over, Centrism Has To Stop - Duration: 3:44.

-------------------------------------------

New Giant Box Dinotrux Surprise Toys Dreamworks Dinosaur Trucks Unboxing Top 10 - Duration: 8:43.

Wow guys today we have a giant box of

New Giant Box Dinotrux Surprise Toys Dreamworks Dinosaur Trucks Unboxing Top 10

these are all our new toys I am box if

you do want to see the unboxing and

dinosaur battles and a lot of fun stuff

go to the playlist at the end of this

video i will have dinotrux playlist

ok let's see what's in here ok the first

time we have is a giant talking rolling

sky

yeah so if you push her she lifts her

head and make different sounds up

and she also roles and she's a lot of

fun and then the next one is talking

Boozer off here

cool is there and then we have a giant

talking garbey if you are you load balls

into its mouth here and when you pull up

the back and shoot the balls out the

back side one in this was a lot of fun

and then of course there best one huge

fucking time rocks toy when you push it

besides the down reading all coming

through

roars I can get eyes light up

let's get building means tie rocks but

you go because I and he has a giant

swinging here so this guy through and

then we have a giant's kya off playset

this 1i has a working

look here that goes up and down her

mouth opens and closes you could leave

her former to create a ramp for the dyno

truck choice to go flying down flying up

into the air so this set is a lot of one

and then we have a talking shadow time

my way

Raptors can't stand those guys

match the brain power

this one has like God like a claw on the

back you can use fixed up off and then

them up down here so this guy's and then

we have a giant destructs place that if

you do it on certain models time is

multiple snap i got me

we have a talking toy trucks puppet tie

rocks job help we got a giant talking

rabbit with this spinning bit up here

you can change out to different bits and

he has a tape measure ton i want another

talking tie rocks play with

got a big rolling tun tun if you roll

him his back of the Don and his head

also pull back

destructor you can pull it back he'll

run and also his mouth up and down i

also have reviews of all their story

sets and all da dr gasps figures

let's see who we've got ok first we got

the diecast garbey diecast tun tun we've

got a big diecast tie rocks another

smaller diecast my rocks and still

another diecast I rocks

we've got to die cast destructs

and then we have two more diecast tie

rocks figures so we actually have five

on diecast tie rocks fingers

some are different this was a really

nice shiny ones that came with one set

and then we have a diecast sky

we've got a diecast dozer diecast

rolling on diecast tun tun we've got

looks like four diecast rabbits another

diecast on so we got two of those toward

tool we've got three diecast or tools

the reason i have so many doubles and

triples is some of these come in sets so

that is pretty cool and then a scrap

grandpa dactyl why actually this is a I

believe this is scott tactical apologize

this is scrapping dactyl so this guy is

really cool in we've got three Raptors

here this one actually rolls and then we

have diecast wall though and the couple

other are miscellaneous diecast so you

can see here i got a huge file these are

all my diecast dinotrux figures so I got

a lot of them besides the big so like i

said if you go to

in this video I've got full reviews of

all of these unboxing them and also fun

story lines where they have to protect

themselves drastic world dinosaurs and

it's a lot of fun

yeah that was a lot of fun and if you

enjoyed the video make sure you click

subscribe and thumbs up button down

below the video in today's secret word

is the word going to put that in the

comments section below the video I know

you remember my club look to the video

and there is it also the curve is off

more fun with you

click the boxes below for a lot more fun

videos and if you want to see even more

go ahead and click the subscribe button

For more infomation >> New Giant Box Dinotrux Surprise Toys Dreamworks Dinosaur Trucks Unboxing Top 10 - Duration: 8:43.

-------------------------------------------

Volvo V70 2.4T wymiana filtra powietrza - Duration: 1:42.

For more infomation >> Volvo V70 2.4T wymiana filtra powietrza - Duration: 1:42.

-------------------------------------------

Preparedness After the Election - Dynasty Preppers - Duration: 6:34.

Hey everyone it's Alexis and Justin from Dynasty Preppers.

And today we just wanted to take a second to kind of talk about the elephant in the

room we have been hearing about lately ever since the election is I need to stop I'm going

to stop preparing and new president stop preparing.

Stay tuned after the jump to see our thoughts on that.

Alright so something we have been seeing a lot of lately is people talking about how

they don't need to be prepared anymore after the election and we wanted to take a second

and talk about that..exactly.. because I think that one that's completely false .. and stupid,

oh my gosh is the President going to save you from so our biggest thing right is that

we are prepared for like the things that are probably going to happen to you right like.

Prepare for the little things in life and you will be prepared for other things.

Loss of job, a sick kid, I mean a death in the family, a blizzard, the loss of your primary

provider of you know income you know all those little things that are likely to happen I

mean we don't try to be the tin foil hat preppers that say the sun is falling, no you know we

are not like the Zombies are coming.

Yeah, but It's prepare for the little things and you know a change in the Presidency, one

really isn't going to change anything overall or quickly.

One person cannot fix everything that is broken.

And even if he does go in and fix most everything that is wrong with the economy and everything

else like that, which probably won't happen, its not going to affect when you loose your

job and can't work anymore and can't find a new job, that's not going to help you.

Right, or when you get snowed in, or fire takes your house, hurricane I mean all the

other thingst that are really likely to happen.

I mean you are much more likely for any of those things, and that's why we prepare.

We are not so, yeah, of course those things are in the back of our mind that ok, some

of these things could happen right, like collapse of society for awhile or anything, yeah but

certain things of course, and things like the economy I think everyone is you know a

little fearful about that with the state of it right now.

Right.

That shouldn't be your main driving force for being prepared.

I think that when you become a parent you should have those thoughts of how do I protect

my family, how to I take care of my family, how do you feed your family, Right.

The important things you know right?

Like if Justin were to loose his job, you know, that would impact our family, right

so, we you know stockpile food, that we eat we don't stockpile you know.

We don't have 25 years of shelf stable food, right no you know, of course i'd like some

of those things you know and I think that there is a place for those things.

Right.

But starting off or even just general things that if everybody had two weeks of food, or

a month of food.

I mean if during a hurricane you had three days of water, or a weeks worth of water and

food.

I mean the outcomes you wouldn't see people standing in line for water from FEMA and other

things like that, so.

And thats our thing we don't want to stand in a food line, we don't want to stand in

a water line, we don't want to yeah so make sure that you keep preparing for those little

things, you know, have an emergency fund for your money, you know, have water for a few

days, have food.

If everybody did just even three days, which like is the bare minimum to me like I would

still feel totally unprepared if we had just three days, but if everybody did that can

you imagine like the outcomes of all these things that happen to everybody?

It would be so much different yeah.

A lot of things would be easier, so I guess in short we just want to say you still should

be Prepared.

I don't think there is any reason to stop being prepared.

Yeah.

And you know one guy isn't going to fix everything.

No, yeah we don't believe that, you know yeah of course nobody is going to fix everything

and be prepared for like the things I said that are going to happen to you, that are

going to happen to your family the more likely tings like in medical preparedness or in medical

anything they say the norm is you know the majority of what people are sick with right?

Like when you go to the Doctor they don't look for the uncommon, they look for the common,

which is 90% of the time something that is going to happen.

So the common things that are going to happen to you are loss of job, natural disaster,

somebody goes to the hospital, someone's sick, someone dies.

All those things that you can still have preparations for and it's not going to, you know the things

like the President arn't going to affect it so.

But that's our two cents on it, so definitely I hope that maybe the new President will change

things somewhat, although I'm not hopeful, i'm not going to hold my breath on that, no,

but so in short keep being prepared.

Keep looking out for thins to do for your family, getting training, training would be

a good thing to invest in.

You know, basic things, one of the things we would like to do is give you guys a little

kinda class on starting from scratch and you know being more prepared.

Because we think it's still important.

We do we think its very important.

So that's what is going to be coming up from us.

Be on the watch out for just basic preparedness, starting from nothing, and deciding where

you want to take that.

Because even if you don't want to take it more thank three days of food and three days

of water, I would still rather have everybody have that then the people that have nothing.

You know anything will help and I think thats a good thing to take away is that you know

anything you do can help you in any situation like that, so.

Don't put your hopes on one person.

Right.

And keep doing what your doing and hopefully you will be better off in the end whether

things get worse or better, you will still be better off in the end.

Thanks for listening to our ramblings.

Subscribe to our channel!

For more infomation >> Preparedness After the Election - Dynasty Preppers - Duration: 6:34.

-------------------------------------------

Top 08: Videojuegos Prometedores que Decepcionaron - Pepe el Mago - Duration: 9:37.

For more infomation >> Top 08: Videojuegos Prometedores que Decepcionaron - Pepe el Mago - Duration: 9:37.

-------------------------------------------

Germany: New Years Message by Merkel's Opponent, Dr. Frauke Petry - Duration: 11:49.

Ladies and gentlemen, dear compatriots

2016 will stay in our memories as the year terror came to Germany

We experienced attacks of radical islamists in Würzburg, Ansbach and Berlin

People were taken from us, many others were injured severely

I'd like to wish all those who have lost a loved much strength in overcoming these horrendous events

I wish the injured a swift and preferably full recovery

My thanks particularly goes out to the police officers today, who fight terrorists at the risk of their lives and pursue criminals daily

These officers must carry out their duties according to the will of political decision-makers

whilst being under-staffed and under-equipped

Even so, the police is often put under general suspicion in public

Their actions questioned, even when officers are defending our lives

I would also like to thank all the paramedics who help the injured and victims of crime, not uncommonly risking their own health in the process

I thank all tax-payers, the very people who come up with the necessary billions that finance the consequences of a gigantic political mistake

We consider the limitless immigration policies of the current federal government to be utterly wrong

Even so, I would like to express my recognition to all who, through their work,

first filled the coffers of the state out of which the money is now being distributed so freely without asking the donors

Last but not least, I would like to thank everyone who went to the state elections in 2016

In all states, we had a significantly higher turnout than in the previous years

Germany has not been this politicised in a long time

Many people who had given up and withdrew are now making use of their right to vote again

This is good for the democracy in our country

Alternative für Deutschland (AfD) is often accused of being a party that wants to go back to the past

It depends on which past is meant by that

There was once a Federal Republic of Germany without islamic terror and without exploding crime rates

A past in which a woman being dragged behind a car by a rope would have been unthinkable (see description)

Unthinkable that women and girls would be mass sexually assaulted and raped

There was a time when very few people were scared to openly voice their opinion

A time when we didn't have a state-financed thought police on the internet

A time without a systematic breach of laws by the state

I know that many people long to be back in those peaceful times

We want to make those past times a thing of the future

Dear compatriots, 2016 was a year full of contradictions

On one hand, the so-called "fight against the right-wing" (Kampf gegen Rechts) was conjured up hysterically

Which is, however, increasingly being directed at the mainstream middle class

Simultaneously, it was a year in which we experienced brutal crimes committed by migrants

These violent criminals were let into our country uncontrolled and in violation of our basic law (Grundgesetz)

Of course by far not all migrants are religious extremists or criminals

Many truly did have good reason to flee from their countries

But especially in their interest, it's so important to identify radical islamists, sentence criminals and resolutely deport them

The federal government is failing at this task

Those who point that out are not agitators, not even right-wing populists but simply realists

2016 was a year full of contradictions

I want to remind of facts that were lost in the mainstream news

Greece, despite the billions in monetary gifts, did not recover but is in fact as ill as ever

Just that Germans today must vouch for additional billion Euro loans

2016 was also the year in which the European central bank pursued its fatal zero-interest policy

pillaging the assets of small savers in order to artificially keep the failed Euro alive

2016 was the year in which every last one of us was able to comprehend that the renewable energy policy has failed

The citizens will receive the bill for this from tomorrow onwards, once again energy prices are rising,

Once again billions are distributed from the bottom to the top

In 2016, it became apparent to every realist that Germany and Europe hasn't been this isolated since 1949

The East Europeans as well as the West Europeans are turning away from Germany's special path

Dear compatriots, 2016 was the year in which the political establishment reached new levels of cynicism

The female mayor of Cologne recommended that all women protect themselves from sex attackers and rapists by keeping an arm lengths distance

The chancellor (Merkel) on the other hand recommended playing the flute as a defence strategy against Islamism (see description)

The governments helplessness and also its indifference towards those they govern cannot be illustrated more clearly

2016 however also demonstrated that a change is possible

We were witnesses of a historic event

The election of Donald Trump as the 45th president of the United States

Even if the political sphere appears immobile, even if the politicians are seemingly firmly established, America has shown it's possible to vote them out

"We want our country back", was Trump's central election campaign message

It was a "declaration of war" against the establishment

Ladies and gentlemen, the Brits also said "We want our country back" some time ago

The election of Trump was, in a way, the American version of Brexit

"We want our country back" is also what many Austrians, French, Belgians and Swedes say

The Zeitgeist ist changing

AfD's (Alternative for Germany) election successes is also proof thereof

We too want our country back

We want it back from the "Merkel government" before she has ruined it with her grotesque politics

We want it back from the Eurocracy in Brussels, which wants an entire continent to submit to their centralised regime

We want it back from the European central bank, which is devaluing our money

We want it back from the clans and gangs who moved here and are terrifying entire neighbourhoods

We want it back from the liberal media landscape that has created a climate of permanent suspicion and moral blackmail

We want to break free from the chains that have made this country forget how to breathe freely

The reasons for the political change in the U.S.A. are being denied by the political class in Germany and also by most journalists to this day

In Western societies, a large rift is dividing the politically correct establishment and the citizens, who fight for their existence by going to work every day

The reactions to Brexit or the election of Donald Trump were more excessive and foolhardy in Germany than in any other European country

It must be a one-off occurrence that a German government leader (Merkel) would want to dictate moral

requirements to the elected U.S. president in order to ensure a future cooperation

Of all things, from a chancellor who made breaching the law her maxim

Germany, as she always likes to say, is a strong country

That's thankfully true

However, Germany is losing more and more of its original strength every year under this chancellor

This strength consists of the diligence of many workers, craftsmen and innovative scientists

Germany remains to be a country of ideas and patents, of inventors and thinkers

2017 will be the year we must refocus on our strength

It's not without alternative that Germany is at this stage merely mediocre when it comes to education worldwide

It's not without alternative that German students know less about math than students in Singapore

That 12 year olds are educated about sexual practices in this country, instead of about poets and a basic knowledge of the sciences

It's not without alternative that the crime rate of immigrants is rising

And its not without alternative that billions of the national wealth is not being spent on German interests

In the coming year, crucial elections will be taking place in Germany and neighbouring countries

Parliamentary elections in the Netherlands, presidential elections in France,

On the 14th of May, the so-called small parliamentary elections in North Rhine-Westphalia

And in autumn, the elections for the 19th German Bundestag

Many people tell themselves "those up there" do what they want anyway

What am I able to change with my vote?

The truth is, there is only one democratic way to stop the establishment from following it's wrong path at our cost

And it's your vote

It's possible to fundamentally change the politics that are harming us

It's possible to defend ones own convictions

It's possible to make Germany go from the madhouse of Europe to a once again respected member of the community

Dear compatriots, what we want is a free Europe of sovereign people, not a Brussels-based central government

The Germany we strive for will be open to all who want to and are able to be active members of a liberal, constitutional society

those who work, do research, invest, learn, teach, create art, or enjoy

and to those who behave in a decent manner

But it's not open to those who pillage this country and its taxpayers, attack or want to missionize

The Germany we strive for will be open to all who integrate themselves,

but not to those who want to live by their own laws and who direct demands at the German society

despite not contributing anything to this society

We strive for a Germany that focuses on its actual potential, the strengths of its skilled workers, engineers, scientists and artists

Unlike a multicultural utopia, this goal is a realistic one and one that is shared by the majority of Germans

The majority of Germans is open and hospitable, not foolish and naive

Dear compatriots, for 2017 I wish you and all of us for it to be a year we can ward off terror

A year in which many things will change for the better, a year of reason

But also a year in which you will hopefully be able to spend more time with your families

Perhaps also a year in which you may rediscover our countries traditions

Let me end with verses from one of the most beautiful German poems, from Berthold Brechts Children's Hymn

Grace spare not and spare no labour,

Passion nor intelligence

That a decent German nation Flourish as do other lands

And because we'll make it better, Let us guard and love our home,

Love it as our dearest country As the others love their own.

I wish you blessed year 2017

For more infomation >> Germany: New Years Message by Merkel's Opponent, Dr. Frauke Petry - Duration: 11:49.

-------------------------------------------

Tela Piscando - Como Resolver - Duration: 3:26.

For more infomation >> Tela Piscando - Como Resolver - Duration: 3:26.

-------------------------------------------

Where can I find some discipline? - Duration: 3:14.

For more infomation >> Where can I find some discipline? - Duration: 3:14.

-------------------------------------------

Opioid dependence & opioid use disorder - Duration: 14:00.

Worldwide, opioids are the most common cause of drug related deaths.

The number of individuals abusing them has quadrupled in the last 20 years, with an uptick

in heroin use, an even bigger uptick in prescription opioid use, and a large group of folks abusing

both.

Because of their potential for addiction and overdose, opioids are regulated substances

in a lot of countries.

As a class, opioids share one thing in common—they bind to opioid receptors in the brain, spinal

cord, and gastrointestinal tract.

Some are endogenous, meaning that they are produced naturally by the body, like endorphin,

short for endogenous morphine.

But others are exogenous, meaning that they come from the environment, like heroin and

morphine because they come from the opium poppy—a flowering plant that oozes out a

milky white liquid, while others like fentanyl are synthesized in the laboratory.

To understand how opioids work, let's zoom into a region of the brain tissue that has

opioid receptors.

Normally, in the absence of endorphins, inhibitory neurons secrete a neurotransmitter that prevents

nearby neurons from releasing the neurotransmitter dopamine.

Now, let's say someone goes to play a rigorous game of badminton.

Exercise releases endorphins which activate the three major opioid receptors located on

the inhibitory neurons, called the mu, kappa, and delta receptors.

As endorphins binds to these receptors, they block the inhibitory neuron from releasing

neurotransmitters, allowing the dopamine secreting neurons to freely unload dopamine.

The dopamine then gets picked up by a third neuron in the same area.

When dopamine release takes place in pain processing regions of the brain like the thalamus,

brainstem, and spinal cord, the result is feeling less pain.

When dopamine release takes place in reward pathway regions like the ventral tegmental

area, nucleus accumbens, and prefrontal cortex, the result is a calming effect that feels

good.

So that's how it works normally.

But when a powerful exogenous opioid binds to the opioid receptors, the result is a massive

flood of dopamine.

This helps with pain control, but it can also cause an incredible state of euphoria within

the regions of the brain involved in the reward pathway, which is an emotional "high".

Now remember, the purpose of the reward pathway is to train the brain to repeat activities

that cause dopamine-mediated pleasure, so when opioids stimulate this reward pathway,

the brain learns to do that behavior again and again.

With exogenous opioids there are multiple routes to get the drug to the brain.

One way is by ingesting it, but that route is the slowest.

A faster route would be inhalation, because the drug is rapidly absorbed through the lungs.

The fastest route, though, is direct injection of the substance into the blood.

Typically, the faster the exogenous opioid reaches the brain the stronger the relationship

between the behavior and the reward.

Now over time, people that are consistently using a drug, even when taking them as exactly

as prescribed, can develop tolerance which means that with repeated use, they have a

reduced response, and therefore an increased dose is needed to achieve the original response.

At a cellular level, there are two theories that explain why this might happen.

One theory is that opioid receptors might become less sensitive to a drug, and the other

theory is that the neurons may remove opioid receptors from the cell wall in a process

called down-regulation, leaving less receptors available for binding.

In either scenario, tolerance leads to the need for higher and higher doses of a drug,

and often times that tolerance remains for a long time even after tapering from the drug.

Alright, so now let's say that you're at rest, there aren't any drugs or anything

stimulating your reward pathway.

In this situation, your brain keeps your heart rate, blood pressure, and wakefulness in a

normal state, called homeostasis.

Now, let's say that your secret crush sends you a text.

All of a sudden you may feel sweaty and flushed, your heart rate may jump a bit.

You're now above your normal level of homeostasis, because something has changed, right?

But it doesn't stay that way for long, and after the text message, your brain brings

things back down to this baseline.

With repeated drug use, a few things start to happen.

Let's say you take the drug at a specific time and setting, like 3pm in the bedroom,

and, being a depressant, it makes everything go lower, heart rate, blood pressure, and

wakefulness.

Your brain being the smart brain that it is, will pick up on the pattern.

Now, next time, at 3pm in the bedroom, the brain preemptively increases each one, since

it knows that when you take the drug, everything's going to decrease again.

Now, let's say 3pm in the bedroom rolls around, but there's no drug...In that situation,

the brain still increases everything..but the changes aren't countered with the effects

of the drug, and so the person can feel awful, and these are called withdrawal symptoms.

These symptoms can persist to the point where a person may need drugs just to feel normal,

and if that's the case, they are considered to be dependent on that drug.

Now, on the flip side, let's say that you use the drug in an unfamiliar setting, like

at 11pm at a party.

Well in that situation, your body's not ready for the drug and there's no physiologic

"counterbalance" to help offset the effect of the drug.

When that's the case, it can lead to overdose, even on a dose that the person's been normally

taking, and that's often times what happens.

The symptoms of opioid withdrawal include anxiety, shivering, tremors, yawning, body

aches, vomiting, diarrhea, abdominal cramps, runny nose, sneezing, sweating, and an increased

heart rate and blood pressure.

These symptoms can feel really awful, and often prompts people to use opioids again;

a process called negative reinforcement, since you're removing the drug, which causes withdrawal

symptoms which reinforces more drug use to avoid those symptoms.

There is also positive reinforcement from the dopamine-induced euphoria, again leading

to more drug use.

Together this positive and negative reinforcement leads to opioid addiction also known as opioid

use disorder.

The DSM-5 or Diagnostic and Statistical Manual, the 5th edition, defines opioid use disorder

as causing at least two of the following behavior patterns within a year: 1.

Using more opioids or using them for longer than intended.

2.

Being unable to cut down on the use of opioids.

3.

Having opioid use take up a significant amount of time 4.

Having cravings to use opioids.

5.

Having opioid use affect responsibilities at work, school, or home.

6.

Using opioids even if they cause recurrent interpersonal problems 7.

Giving up important activities in order to use opioids.

8.

Using opioids in physically dangerous situations.

9.

Using opioids even if its worsening a physical or psychological problem 10.

Becoming tolerant to the opioids.

And finally 11.

Feeling withdrawal symptoms from opioids.

Having 2 or 3 of these symptoms is considered mild, having 4 or 5 is considered moderate,

and having 6 or more is considered severe.

In addition to ruining a person's life, opioid addiction can also end it in an overdose.

Most often, an opioid overdose causes severe cardiac and respiratory depression, to the

point where a person may have pinpoint pupils and simply stop breathing.

In that situation, the most important thing is to performing rescue breathing, giving

supplemental oxygen, and administering naloxone.

Naloxone is an opioid antagonist that powerfully binds to opioid receptors, and rather than

having a direct effect, it blocks other opioids from binding and activating the receptor.

This works because at any given moment, opioids are binding and unbinding to receptors which

means once an opioid releases its hold on a receptor, the naloxone can simply sneak

in and bind more strongly.

When naloxone given intravenously it can reverse the effects of opioids within minutes, potentially

saving a person's life.

Generally speaking, high doses of strong opioids carry the greatest risk of addiction and death,

and when paired with other substances that can cause respiratory depression, like benzodiazepines,

they're more likely to cause overdose because they can act synergistically to cause respiratory

depression.

It's clear that opioids have strong addictive potential, so their use should be limited

and well defined.

They have a role in controlling acute pain, for example, but the goal should be to use

short-acting opioids at the lowest effective dose for just a few days, and slowly increase

their dose only as needed.

When opioids are used for chronic pain, they should be weaned off as soon as possible,

ideally at a wean rate of 10% of the dose per week.

In general though, chronic pain should be treated with non-opioid approaches.

These include exercise and biofeedback as well as other types of medications such as

acetaminophen and NSAIDs like ibuprofen.

There are also disease-specific treatments, like for migraines use triptans, or for neuropathic

pain use gabapentin, or for joint pain topical pain treatments like capsaicin.

For people with opioid dependence, the most effective treatment is a combination of therapy

with medications.

Specific therapies that work include motivational interviewing, which can be used to understand

why an individual wants to stop using opioids and identify specific barriers to treatment.

Also cognitive-behavioral therapy can help an individual learn about withdrawal, discuss

the thoughts, feelings, and behaviors that lead to opioid usage, and create a plan to

navigate triggers for usage.

Another form of therapy are peer-support programs which use group discussions to help individuals

commit to ending the use of opioids and by holding one another accountable.

In addition, the evidence strongly supports the use of medications, which reliably decrease

cravings and reduce withdrawal symptoms.

Methadone is a full opioid agonist with a long half-life that slowly builds up in the

tissues over time, allowing it to reach a steady-state level within a week.

Steady-state refers to the situation where the overall intake of the drug is more or

less in balance with its elimination, so that the body is exposed to a stable level.

In contrast, buprenorphine is a partial agonist that is sometimes given in combination with

naloxone, forming an agonist/antagonist combination.

Buprenorphine has a ceiling effect, meaning that above a certain dose it does not have

any more of an effect, which reduces the chance of an overdose.

These medications can competitively bind to the opioid receptor without producing the

same euphoria as the opioids they take the place of.

Since they have opioid effects, though, they can cause side effects like constipation,

insomnia, weight gain, hormonal changes, and cardiac arrhythmias.

The good news is that over time, an individual can safely taper their use of opioid treatments

altogether, and this approach is more likely to succeed than simply stopping opioids without

these treatments.

Another medication called naltrexone, can be used for people who are already abstaining

from active opioid use.

Naltrexone is a mu-opioid receptor antagonist that blocks the effects of opioids and helps

maintain abstinence.

Finally, all of these approaches work best when an individual has a strong network of

family and friends offering support.

Opioid use still carries heavy stigma because usage is still tied to a notion of individual

choice and moral failure, even though we now know that opioid use is a consequence of biological,

psychological, and social factors—all of which need to be addressed to maximize the

chances of recovery.

Alright, as a quick recap, opioids stop inhibitory neurons from releasing inhibitory neurotransmitters,

which allows dopamine to flood the ventral tegmental area, nucleus accumbens, and prefrontal

cortex, and causing euphoria.

Long-term use can cause tolerance which is the need for increasing doses to achieve the

same effect, as well as dependence which is the reliance on the opioid to function normally.

The most effective treatment is a combination of therapy and medications, with a lot of

love and support from family and friends.

Thanks for watching, you can help support us by donating on patreon, or subscribing

to our channel, or telling your friends about us on social media.

For more infomation >> Opioid dependence & opioid use disorder - Duration: 14:00.

-------------------------------------------

How to Set Objectives, KPI's, and Key Supporting Messages - Duration: 2:55.

Setting Objectives, KPIs and Key Messages

In order to produce a social media strategy that makes the best use of

your resources, it must be guided by goals that directly contribute

to the larger business objectives of your company.

Each social media goal you establish must be specific, measurable,

attainable, realistic, and time-bound. To make a goal specific, it should

focus on a precise area of improvement. To test how measurable your goal is,

ask yourself: can you set a target for the goal?

Will you be able to tell when a goal is half complete?

For example, a goal of a 15% increase in web traffic in 4 months is measurable.

A goal to "be more engaging on social media" is not.

In order to be attainable and realistic, consider the goal in an historical

context and evaluate your resources. For example, if your sales have

been growing by 25% every quarter, seeking 200% growth in 3 months

would not be realistic, unless you're also planning to triple the size

of your sales team. Lastly, put a timeframe on your goal

in order to measure success and benchmark progress.

Say you're a local tourist attraction and your business objective is to increase

ticket sales by 15% in 6 months. Your corresponding social media goal

could therefore be to increase unique visitors to your website from

your social media properties by 30% in 6 months.

In this case, your key performance indicator or KPI would be the

number of unique visitors your website receives from your Twitter, Google+

and Facebook profiles over the course of those 6 months.

If you're an online retailer, your social media goal may be to

increase newsletter sign ups from social channels by 30% in 4 months.

Your KPI would be the number of sign ups you receive, which you can

track with Google Analytics. When setting KPIs it's important

to ask yourself what exactly they will help you achieve.

In this case, a larger email list may let you send out better

targeted email campaigns. Once you've established your

social media goals, you'll need to figure out your key messages.

Simply put, a key message is what you want the public to know about your business.

Sync with your marketing department to see if they could share any previously

developed brand positioning statements. Going back to the tourist attraction

example, the key message may be "A Thrilling Adventure

in the Heart of the City." With that message in mind, how you talk

to your audience and what you emphasize about your business will flow

from that central descriptor. Lastly, to ensure that your social media

goals are holistic and reflective of larger business goals, take the time to sync with

your company's business development and marketing departments.

Together, you can review your objectives, KPIs and targets to ensure

that the social strategy you're putting in place complements the work that's

being done across the company.

For more infomation >> How to Set Objectives, KPI's, and Key Supporting Messages - Duration: 2:55.

-------------------------------------------

ENGsub + VIETsub | GOBLIN GONG YOO ver. and REAL ver. - Duration: 1:08.

Solo TV????? Oh, my gosh!

With any contents and you press this red button

Instantly switches to solo mode

Oh, just press this one?

So, do you once experience the trial contents of the solo TV yet?

First, awesome drama which most beloved

GOBLIN

Why am i doing this? There is no God

You?

Me? You?

Did you call me?

Me?

No. This scene... how's solo mode?

Why am i doing this? There is no God

You?

A handsome goblin like Gong Yoo is coming, right?

Oh my!

Who are you?

I... am goblin~!

Go away!

Ah~ my eyes! I have only one eye, I can't see

It's scary and fresh!

Drama can be much more interesting without romance

For more infomation >> ENGsub + VIETsub | GOBLIN GONG YOO ver. and REAL ver. - Duration: 1:08.

-------------------------------------------

Момент крушения Ту 154 в деталях. (04.01.2017) - Duration: 2:14.

For more infomation >> Момент крушения Ту 154 в деталях. (04.01.2017) - Duration: 2:14.

-------------------------------------------

"Of Love And Latkes" | A Hanukkah Story Read By Susan Stamberg And Murray Horwitz | NPR - Duration: 14:44.

Ava met Yakov on Bingo night at Beth Israel Senior Center.

She helped him find the words on the board and they got to talking.

Yakov had lost his wife, Clara, a few months before.

Ava had been a widow for five years.

They discovered they were both from the same region in the Ukraine and had lived in Brooklyn

for about the same length of time.

Yakov had food stains on his shirt and old tissues stuffed in his pocket.

But what really got to Ava was a pitiful margarine sandwich Yakov extracted from the inside of his jacket.

She asked if he'd like to come over for dinner and he said yes.

It was good to have someone to cook for again.

With Sam, her late husband, they had such wonderful meals.

Cooking had always been a passion, but cooking for Sam was especially satisfying as no one

was more appreciative of her creations than he.

He smacked his lips and licked his fingers, declaring her the best cook in all of Brooklyn

or possibly even the whole of New York.

Now, stirring plump Frikadelki in golden broth, Ava imagined Yakov's exaltations

and her heart expanded.

Yakov arrived with a bouquet of flowers.

He was full of compliments for her apartment – how clean it was, how tastefully arranged.

He examined the photographs of her grown grandchildren, pronouncing them handsome and bright.

He was helpful too, setting the table while she ladled the soup into bowls.

She watched him take a spoonful, then another, gulping the soup down with eagerness that

suggested it pleased him.

But he was oddly silent, no exclamations of delight or words of appreciation.

"How is it?" she asked.

"Em,"

"Thank you very much."

She served the main course – chicken breast with a side of rice and a nice green salad

– all to the same effect.

Yakov consumed his portion with relish but said little more than thank you in response.

After dinner he told her about his childhood as a son of party activists.

How at a very young age he had learned to take care of the house, cleaning and cooking

(mostly noodles) in time for his parents' return.

"You poor thing," Ava said, recalling the homemade delicacies her mother had put out for her.

Yakov smiled at that, "Sometimes I thought so too.

Other times, I didn't mind so much."

They made tea and Ava served dessert.

"I hope you like jam rolls," she said.

"My mother's recipe."

"Em, thank you," was all he gave her.

"Thank you for inviting me," he said when it was time to go.

"Would you like to come again Tuesday?"

"I'll make borscht."

So it went for several weeks.

Chicken soup, meat patties, pierogi with mushrooms and leeks, olfactory memories of life past

permeating her apartment.

"It's been so long since I've done real cooking," she said to Yakov over a plate of pelmeni.

(These are dumplings.)

"It's not fun to cook just for yourself."

"You can cook for me any time," he declared.

She waited for him to say more, praise the quality of the food and her skill as a cook.

He didn't, but nodded enthusiastically when she asked if he'd like some more.

She wondered why he was so tight lipped when it came to her cooking.

He seemed quite capable of complimenting her on everything else.

For someone who'd grown up on noodles, he turned out to be exceptionally hard to please.

Thanksgiving they spent at their children's.

Seizing a quiet moment alone with her daughter, Ava confided her fears.

"What if I'm not as good a cook as I thought I was?

Who knows what he was used to with Clara?"

"It's not the middle ages, Mama.

There's more to relationships than food."

Ava frowned.

Of course food wasn't everything, but it wasn't nothing either.

These days women thought they could get away with take-out and frozen.

What they failed to understand was that a home cooked meal was more than nourishment.

It was family and belonging, a taste of childhood, a kind of love.

She didn't say any of that to her daughter.

Instead she said, "I want my efforts to be appreciated.

Is that so bad?"

"Why don't you just ask him outright what he thinks of your cooking?" her daughter said.

"Or, if you must, ask him if you cook as well as his wife."

"Are you mad?"

"I could never.

I'll just have to try harder, that's all."

She came home determined.

If everyday meals didn't do the trick, surely her specials would.

Upon his return Yakov was treated to her famed brisket and tzimmes.

(That's a kind of a sweet stew with carrots and prunes and some people put meat into it as well.)

Back in the day this very dish had marked a turnaround in her relationship with her mother-in-law.

"You must love my son very much," the matron had said to Ava with tears in her eyes.

If she could melt her mother-in-law's heart, at the very least she should be able to elicit

a word of acknowledgement from Yakov.

"Are you expecting company?"

Yakov said when she uncovered the brisket.

"No, just you."

"Well, this is … thank you Ava," he devoured his portion and nodded when she offered more.

"Good?" she demanded.

"Em," he shoved another forkful into his mouth. "Thank you."

Why won't he just say the word?

"They didn't feed you at your son's house?" she asked.

He seemed not to notice her sarcasm.

"My daughter in law doesn't cook," he explained then added with a chuckle,

"they said I've gained weight since they last saw me."

So now her food was too fattening?

"Did Clara cook low fat?" she inquired, more than a little peeved.

His expression changed.

"No," he said, so miserable she regretted saying anything.

"Eat, eat," she added tzimmes to his plate.

"If it's any consolation, I think you look good."

He smiled, "not as good as you."

She wondered if her daughter was right.

She enjoyed his company and he enjoyed hers.

Wasn't that enough?

But when she tried to let go of it, it wouldn't let go of her.

His refusal to utter anything more than "em" and "thank you" felt unnatural,

as if he was stopping himself from saying something he'd regret.

For days she agonized over her options.

At last, she had an idea.

"Why don't I cook for you at your place this Friday night?" she said to him.

The things Ava could not ask would be revealed once she'd stepped into Clara's kitchen.

A woman's culinary interest, her skill, manifested itself in her work space,

and who better than Ava to pick up on those subtle indicators.

Yakov seemed reluctant at first.

Ava would find it uncomfortable; the kitchen hasn't been used in a while.

Ava dismissed his excuses.

A change in scenery would do them both good, she said and handed him a list of ingredients.

She brought her set of knives and condiments and it immediately became apparent she shouldn't have bothered.

The kitchen was small but surprisingly well equipped.

Blenders, pressers, crushers, an assortment of spices she didn't know the names for

and a long shelf of cookbooks from Bulgarian to Southern French.

The ingredients she had asked Yakov to buy awaited her on the counter.

How plain her planned dinner seemed compared with the grand meals tucked in those pages.

It took all of Ava's strength to put her apron on and start chopping,

each turn of the knife making her wince.

It didn't help that Yakov kept pressing Clara's fancy tools on her,

"See this, it slices the egg just so, and this is for pitting olives."

"I'll do it my way, thank you very much," she wished she could shoo him out of the kitchen

but this was his home, his and Clara's.

At no time since she'd met Yakov did she feel so out of place.

They lit the Shabbat candles and sat down to eat with a photograph of Clara overseeing their dinner.

Clara's pleasant face wore a sad little smile, as if despite her best efforts

things hadn't turned out quite as she'd hoped.

Ava knew exactly how that felt.

She hardly touched the veal and cauliflower.

Long ago this very dish had her daughter's boyfriend returning until he'd finally proposed.

Now it tasted of caustic embarrassment.

"You're not hungry?" Yakov asked with a mouth full of food.

"No."

"You've tired yourself out with all that cooking," he said.

"Why don't you rest on the couch."

She complied, letting him take off her shoes and place her feet in his lap.

"I used to do that for Clara when she got anxious," he said, massaging her heel.

His hands felt good but Ava could not enjoy them.

"I was wrong to come," she said.

"This dinner, it must remind you of Clara."

"Remind me?

No.

With Clara it was different," he glanced sadly at his unfinished plate.

"Completely different."

That was it then, the terrible truth.

No matter how she tried she would always come short.

His eagerness that she'd mistaken for satisfaction was nothing more than a rush to be done with her food.

And she, the fool that she was, kept offering him second helpings!

She got up from the couch.

"I should go," she said, grabbing her coat and purse.

He seemed surprised but didn't try to stop her.

"I'll walk you home," he offered.

"Please don't. I'll be fine."

December wind chilled her all the way home, but she hardly noticed.

Her body was frozen in shame for her arrogance and stupidity.

She had assumed she was giving him something of value when in truth it was an ordeal for him.

He might have thought he was sparing her feelings by keeping silent, but he just made it worse.

He called the next morning.

She didn't pick up.

The day after he left three messages.

The last one sounded quite desperate.

"Call me, please."

She called him.

"Thank God," he said.

"I was about to send in a search party."

"No need, I'm fine."

There was an awkward silence then he said, "Tomorrow is the first night of Hannukah.

I thought we could light candles, eat some latkes.

Not that I want you to cook," he added quickly.

"God knows you've cooked enough.

They sell frozen latkes at…"

"I can make Latkes, Yakov," she cut him off.

"Of course you can," he agreed.

"Should we say five o'clock?"

"Five is fine," she hung up, fuming.

Latkes he wanted to spare her, latkes that she could whip up with her eyes closed and

both hands tied behind her back.

Oh, the wonderful latkes she used to make for Sam: potato and leek, sweet potato and

raisin, zucchini patties and bite sized fried Salmon balls.

Her husband never had to eat the same Latke twice…

But no sooner had she recalled her past achievements, than her gloom returned.

No matter what she did, the memory of Clara's cooking would always hover over Yakov

and her like a bitter aftertaste.

If only she could care less, put a little less soul into her cooking, but that was like

asking her to love with less heart.

She went to bed on an empty stomach.

In her dreams Clara was serving her latkes, golden and fluffy like Ava's mother used to make.

She awoke sore and morose.

By midday, when the time came to start frying, she was perfectly despondent.

She had cut herself twice on the grater, something she hadn't done since she'd learned how to grate.

She had poured too much oil and it hissed and spit, covering her bare arms with tiny burns.

She recalled how long ago when her teenage daughter rejected her cooking, her husband

had tried to console her.

"Sometimes love is knowing what's needed, not giving all you can give," he had said.

She was mad at him for saying that, as if she didn't know her own child, but he was right.

She wanted to make her daughter happy her way, just as she did with Yakov.

When Yakov showed up he found the apartment smoky and Ava in tears.

"What happened? Did you hurt yourself?"

She pointed at a pile of black bottomed latkes, "I was a fool, trying to impress you with

my cooking, when in truth I'm quite mediocre, certainly not as good as your Clara."

He stared at her, speechless, then burst out laughing, so hard she feared he might break a rib.

"Oh God Ava.

I miss Clara, I do, but her cooking," he picked up a scorched latke.

"This is the closest you ever got to Clara's cooking.

Clara was a wonderful, sensitive person but a terrible, terrible cook."

"But all those cookbooks, the tools!"

"She kept trying, hoping it would make a difference. It didn't.

It was her biggest disappointment."

"Why didn't you tell me?"

"I didn't know I needed to.

Clara was so insecure about her cooking even compliments made her cry.

I learned to say thank you and nothing more."

He took Ava's hand and kissed the inside of her palm.

"I loved every single thing you made for me."

Ava cupped his face in her hands and kissed him for the longest time.

Tomorrow she would make spicy squash latkes to go with the second candle.

She had so much more to give.

Không có nhận xét nào:

Đăng nhận xét