the presynaptic neuromuscular nerve
ending contains membranous testicles
prepared to release its stored
neurotransmitter acetylcholine neuronal
stimulation initiates a cascade of
events that leads to the fusion of the
neurotransmitter containing vesicle with
a nerve membrane this process is
facilitated by a group of proteins
comprising the snare complex the
membrane fusion results in the release
of acetylcholine into the synaptic cleft
by a process of exocytosis the fetal
clothing diffuses and eventually binds
to receptors on the muscle leading to
muscle contraction
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Botox botulinum toxin tybee consists of
a heavy chain of 100 kiloton and a light
chain of 50 kiloton alt making up the
150 kiloton court I've a molecule the
toxin is protected by accessory
hemagglutinin and non-toxic non
hemagglutinin proteins yielding a
uniform 900 killer doll and complex
this illustration shows a cross-section
of the spine with a motor neuron
extending into the muscle and the
sensory neuron extending out of the
Muslim after injection of Botox it would
be expected that most of the neurotoxin
would remain at the injection site the
Botox or molecule dissociates from the
accessory proteins and targets the nerve
endings the binding domain of the Botox
core molecule is the c-terminal portion
of the heavy chick with an accepted on
earth the Botox core molecule enters the
nerve cell by a process of
receptor-mediated endocytosis it is the
heavy chain that contains the binding
domain the toxin is now contained in a
membranous vesicle in cyber cell soon
after the light chain is released into
the cytoplasm of the nerve terminal
where it begins to clean one of the
snare proteins
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in motor neurons the light chain of the
Botox core molecule blocks the release
of acetylcholine like leaving snap-25
which is an essential component of the
snare complex when acetylcholine cannot
be released muscle contraction cannot
occur in sensory neurons the light
chains believe to clean snap-25 by a
similar mechanism thereby blocking the
release of neuropeptide
neurotransmitters and inhibiting the
sensitization of painters the toxin does
not appear to affect the conduction of
electrical signals along the nerve life
or the synthesis or storage of
acetylcholine indication cervical
dystonia Botox is indicated for the
treatment of cervical dystonia in adults
to decrease the severity of abnormal
position and neck pain associated with
cervical dystonia bloodless tasm and
strabismus Botox is indicated for the
treatment of strabismus and
blepharospasm associated with dystonia
including the nine essential
blepharospasm or seventh nerve disorders
and patience 12 years of age and above
the efficacy and safety of Botox
treatment and deviations over 50 prison
doctors and restrictive store business
in twain syndrome with lateral weakness
and secondary strabismus caused by prior
surgical over recession of the
antagonist has not been established
Botox is infected in chronic paralytics
for business except when used in
conjunction with surgical repair to
reduce antagonist contracture
hyperhidrosis Botox is indicated for the
treatment of severe primary access Larry
hyperhidrosis spreaders and adequately
manage with topical agent important
safety information contraindications and
wardens contraindications Botox
treatment is contraindicated in the
presence of infection that the proposed
injection site or sites and individuals
with known hypersensitivity to any
ingredient in the formulation warning
the recommended dosage and frequency of
administration of Botox should not be
exceeded risks resulting from
administration at higher doses are not
no serious and or immediate
hypersensitivity reactions have been
rarely reported these reactions include
anaphylaxis verdict area soft-tissue
edema and dyspnea if such a reaction
occurs further Botox injection should be
discontinued
appropriate medical therapy immediately
Institute patients with peripheral
neuropathic diseases for example
amyotrophic lateral sclerosis or motor
neuropathy or neuromuscular Junction
disorders such as myasthenia gravis or
lambert-eaton syndrome should only
received Botox treatment with caution
patients with neuromuscular disorders
may be at increased risk of clinically
significant systemic effects including
severe dysplasia and respiratory
compromise from typical Botox Kosan
important safety information adverse
event general there have been rare
spontaneous reports of death sometimes
associated with dysplasia pneumonia and
other significant disability or
anaphylaxis after treatment with
botulinum toxin there have been reports
of adverse events involving the
cardiovascular system cervical dystonia
the most frequently reported adverse
reaction from patients with cervical
dystonia following Botox injection our
decision nineteen percent upper
respiratory infection 12% McCain eleven
percent and heading 11-percent
blepharospasm the most frequently
reported treatment-related adverse
reactions and leftist presentations
following Botox injection artosis 20.8
percent superficial punctate
characteristics 6.3 percent and I
dryness 6.3 percent hyperhidrosis the
most frequently reported adverse events
3% 210 precipitation following Botox
injection or injection site pain and
hemorrhage not actually sweating in
Section pharyngitis through syndrome at
a fever
negar back pain brightest and anxiety
please refer the full prescribing
information
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